Cannabinoid Receptors (CB Receptor)
The receptors in the brain and body that interact with cannabinoids where ever they are created.
Cannabinoids – Compounds found both in our body and in nature (not just in cannabis) that interact with our CB receptors and Endocannabinoid system that alter neuro-response.
Endocannabinoid System – The system in which cannabinoids are used to regulate many of your bodies base processes including but not limited to motor learning, synaptic plasticity, stress response, hormone response and many other vital systems.
Cannabinol (CBN) – A mildly psychoactive cannabinoid that comes about from the degradation of THC, there is usually very little to no CBN in a fresh plant. CBN acts as a weak agonist at both the CB1 & CB2 receptors having greater affinity for CB2 over CB1. The degradation of THC, into CBN, is often described as creating a “couch lock” and sedative effect and potentiates the effects of THC.
Cannabigerol (CBG) – A non-psychoactive cannabinoid, CBG has antibacterial effects and can alter the overall effects of Cannabis. CBG may kills or slow bacterial growth, reduces inflammation (particularly in its acidic CBGA form,) inhibits cell growth in tumor/cancer cells, and promotes bone growth. CBG pharmacological activity at the CB2 receptor is currently unknown and acts as a low affinity antagonist at the CB1 receptor
Cannabichromene (CBC) More common in tropical cannabis varieties. Effects include anti-inflamatory and analgesic. CBC is known to relieve pain (analgesic), reduce inflammation, inhibits cell growth in tumor/cancer cells (anti-proliferative), and promotes bone growth (bone stimulant). The effects of CBC appear to be mediated through non-cannabinoid receptor interactions.
Tetrahydrocannabivarin (THCV) THCV is a minor cannabinoid found in only some strains of cannabis. The only structural difference from THC is the presence of a propyl (3 carbon) instead of a pentyl (5 carbon) group on the molecule. Though this difference is subtle it causes THCV to produce very different effects from THC. Some of these effects include a reduction in panic attacks, suppression of appetite, and the promotion bone growth. THCV acts as an antagonist at the CB1 receptor and a partial agonist at the CB2 receptor.
Cannabidivarin (CBDV) Like THCV, CBDV differs from CBD only by the substitution of a pentyl (5 carbon) for a propyl (3 carbon) side chain. Its mechanism of action has not yet been fully elucidated however recent studies have shown promise for its use in the management of epilepsy due to its action at TRPV1 receptors and modulation of gene expression